![]() ![]() Vice versa, code where derivatives are computed and its respective data type and variables are called active.Ī wide collection of AD tools can be found on the community website 2. For both, tangent and adjoint, the underlying original code is called the primal, and the used floating point data type and its variables are called passive. Derivative information is then propagated through the tape in the adjoint run. In AAD, the program is first executed in the augmented primal run, where required data for later use is stored. This is done using the tangent model in tangent mode or the adjoint model in adjoint mode, where the latter is also known as adjoint AD (AAD). AD enables the computation of derivatives of the output of such programs with respect to their inputs. when performing uncertainty quantification , sensitivity analysis or shape optimization . Derivatives of computer programs can be of interest, e.g. Chronic congestive heart failure (CHF) is the primary cause of hospitalization in people over the age of 65, affecting about 26 million people globally.Linear algebra library Eigen 1 is used as a base software implementing linear algebra operations for which derivatives are to be computed using Algorithmic Differentiation (AD) by overloading. The related cost in the United States alone is estimated at up to $40 billion. Israeli devices such as Impulse Dynamics’ Optimizer III and BioControl Medical’s CardioFit offer novel treatment options for CHF.Ībout half that amount stems from hospital readmissions - 25 percent of heart-failure patients are readmitted within a month, and half within six months. Here we’ll take a look at some Israeli companies developing better ways to manage and monitor this progressive condition, to improve patients’ quality of life and avoid repeated hospitalizations. Vectorious Medical Technologies of Tel Aviv recently closed a $5 million financing round for the development of its miniature wireless hemodynamic monitoring sensory implant toward first human trials. Among the investors is the Global Cardiovascular Innovation Center of the Cleveland Clinic. “Our solution will make daily monitoring a routine activity for congestive heart failure patients and their physicians, similar to glucose monitoring for diabetes patients,” predicts cofounder and CEO Oren Goldshtein. Vectorious is developing an implantable monitoring device. With the push of a button, patients with the Vectorious implant would get a pressure reading from their heart’s left atrium, which will enable optimal adjustment of their medical treatment. Goldshtein says left atrial pressure provides earlier and more specific indication of cardiac deterioration than does the CardioMEMS device approved by the US Food and Drug Administration last May for measuring pulmonary (lung) artery pressure. That breakthrough American device already is reducing readmissions by up to 40%, and Goldshtein believes Vectorious can be even more effective. It took about four years to develop the first working model of the Vectorious device, expected to be tested this coming year in collaboration with American and Israeli cardiologists. The 10-person company has a subsidiary in Ohio to oversee this next stage. Goldshtein believes the technology infrastructure will have additional applications ahead. While atrial pressure cannot be adequately measured from outside the body, several Israeli companies are taking a different tack by developing noninvasive devices to monitor congestion in the lungs. Most hospital readmissions of CHF patients are due to lung edema (swelling) caused by excess fluid, so it makes sense to identify and treat fluid buildup before edema sets in. ![]() Last year, Sensible Medical Innovations of Kfar Neter received Europe’s CE mark for its ReDS Wearable System for measuring and monitoring lung fluid in hospital, clinic and home. The system will be introduced via commercial pilots in Europe together with Boston Scientific Corporation. “Worsening congestion is a key driver of hospital admission and mortality in patients with heart failure. Identifying and appropriately managing congestion is challenging,” said Dr. “We look forward to seeing how treatment based on accurate lung fluid measurement may help keep patients safe at home and potentially reduce hospitalizations and perhaps even mortality.” John Cleland, chairman of clinical cardiology at the National Heart & Lung Institute of Royal Brompton & Harefield Hospitals in London, and a member of Sensible’s Physician Steering Committee. Kyma Medical Technologies in Kfar Saba recently received CE approval for its next-generation ♜or System, a platform to monitor a patient’s chest fluids, along with other vital signs, in clinical and home environments. ![]()
0 Comments
Leave a Reply. |